CORDIS Project
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This project explores the mechanical forces that regulate cell proliferation and death in epithelial tissues, which are crucial for understanding cancer development. It aims to determine whether cell migration influences these processes and the role of a specific ion channel in cancer-related cell behavior.
Cancers arise in cell types that turnover by proliferation and death at highest rates, likely because these rates become unbalanced.
Our group found that mechanical forces control both processes in epithelia: stretch activates proliferation whereas crowding activates cell extrusion and death.
However, it was unclear what causes crowding and stretching forces in epithelia. I will investigate if cell migration from sites of proliferation drives the conveyor belt forces that control stretch-induced…
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