CORDIS Project
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This project investigates the nuclear pore complexes in progeroid cells to understand how mutations in lamin proteins affect nuclear transport and contribute to premature aging. It employs advanced imaging techniques to visualize these complexes in patient-derived cells.
The nuclear lamina is a meshwork of lamin proteins that underlie the inner nuclear membrane and confer mechanical stability to the nuclear envelope.
Mutations in lamins are associated with many disorders, including Progeria, a fatal premature ageing disease.
In progeroid cells, expression of a truncated form of lamin A, named progerin, drastically deforms the nuclear envelope, causing premature cellular senescence.
However, the underlying molecular mechanisms remain unclear.The nuclear pore comp…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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