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ProForce investigates how mechanical forces influence biological functions at the single-protein level, focusing on low-force regimes. The project aims to develop advanced techniques to measure these forces and explore their implications for health issues like bleeding disorders and cancer.
Mechanical forces play critical roles in the regulation of biological functions, including development, motility, and haemostasis.
Aberrant mechano-regulation is implicated in human pathologies, including cancer and infarction.
Proteins sense forces by undergoing conformational changes under external loads that trigger downstream signaling.
Despite its importance, mechanical regulation at the single-protein level remains poorly understood, in part due to a lack of suitable techniques to probe th…
UNIVERSITAET AUGSBURG
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Netherlands, Utrecht
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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