CORDIS Project
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The project explores the mechanisms of protein misfolding associated with neurodegenerative diseases, particularly focusing on mutant SOD1 in amyotrophic lateral sclerosis. It aims to identify therapeutic strategies to mitigate protein misfolding and enhance cellular resilience.
My long-term goal is to understand, how misfolded proteins, associated with the pathogenesis of most neurodegenerative diseases, propagate in a prion-like manner (i) and to identify strategies that could lead to cure protein misfolding (ii).(i) We have recently discovered that mutant SOD1 aggregates, associated with amyotrophic lateral sclerosis, penetrate inside cells and replicate their misfolded state indefinitely, just like prions.
Using our robust cell-based system, we will identify the mec…
UNITED KINGDOM RESEARCH AND INNOVATION
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United Kingdom, LONDON
Type: Public body
Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
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