CORDIS Project
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This project leverages next-generation sequencing data to analyze protein families and their evolutionary relationships. It focuses on predicting protein structure and function using statistical methods, particularly for challenging proteins like disordered and transmembrane proteins.
As a result of the rapid development of next generation sequencing, we now have access to hundreds and often many thousands of sequences which belong to the same family.
Such a large amount of sequence data for a particular protein family, along with recent developments in computational statistics, enables an entirely new kind of evolutionary analysis to be performed on sequences, where for the first time we can compute statistically significant networks of correlated mutations.
The proposal des…
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