CORDIS Project
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This research focuses on the mechanisms of centrosome clustering in cancer cells, which allows them to survive during cell division. By investigating specific proteins involved in this process, the project aims to develop targeted anti-cancer therapies that inhibit centrosome clustering.
Cancer cells have the tendency to accumulate extra copies of centrosomes, organelles responsible for the microtubules' organization during cell division.
In normal cells, an aberrant number of centrosomes leads to the formation of multipolar spindles, uneven segregation of chromosomes between daughter cells and consequent mitotic catastrophe.
On the contrary, cancer cells are able to form a pseudo-bipolar mitotic spindle by a process called centrosome clustering, which provides survival advantag…
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