CORDIS Project
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This research focuses on the role of sulfation in chemokine signaling. It aims to develop tools to study sulfation patterns and their effects on chemokine-receptor interactions, which could have implications for various biological processes and diseases.
The aim of the research proposed here is to investigate the role of sulfation in general, and more specifically in the context of chemokine signaling.
For this purpose, tools will be developed that can be used to study and to interfere with sulfation.
First of all, activity-based probes (ABPs) will be synthesized for both sulfotransferases and sulfatases by modifying known inhibitors with a (photo)reactive group.
The resulting ABPs will be used to establish the activity of the different enzymes…
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