CORDIS Project
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This project focuses on developing innovative chemical probes to analyze protein interactions related to arginine methylation, a significant post-translational modification. By creating a library of peptide-based and protein-based probes, the project aims to enhance our understanding of cellular processes and their imp…
Protein arginine methylation, catalyzed by a family of enzymes called protein arginine methyltransferases (PRMTs), is emerging as an important post-translational modification (PTM) that modulates diverse cellular processes, and dysregulation of this process has been implicated in many human pathological conditions ranging from heart diseases to cancer.
Proteins that recognize this PTM in vivo and the associated protein-protein interactions (PPI) are responsible for its key biological implication…
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