CORDIS Project
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This project explores the mechanisms of protein misfolding in neurodegenerative diseases, particularly Parkinson's disease. It aims to understand how misfolded proteins spread between cells and influence disease progression, potentially leading to new therapeutic strategies.
Protein misfolding is implicated as a pathogenetic mechanism in several neurodegenerative disorders, including Parkinson¿s disease (PD).
In prion disease, the misfolded protein spreads between cells and acts as a ¿permissive template¿, causing protein in the recipient cell to misfold.
In 2008 we reported that classical neuropathological changes gradually propagate from a PD patient¿s brain to a graft of healthy neurons, over one decade after surgery.
These groundbreaking findings suggest that th…
MAX IV Laboratory, Lund University
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