CORDIS Project
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This project investigates how the bacterium Shigella sonnei survives within human immune cells, focusing on its ability to establish long-term infections. By exploring the role of its surface polysaccharide, the O-antigen, the research aims to enhance understanding of persistent infections and improve strategies for di…
Shigella is a human-adapted invasive pathogen and a high-priority antimicrobial resistance (AMR) threat, responsible for up to 165 million cases of bacillary dysentery and over 200,000 deaths annually.
Emerging evidence shows that certain lineages of Shigella, including Shigella sonnei, can establish long-term infections in patients and animal models.
Persistent infections are a significant public health threat, as they can cause recurrent disease manifestations.
Persistent infections also compl…
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