CORDIS Project
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This project investigates the molecular mechanisms of prion diseases and their similarities with other neurodegenerative disorders like Alzheimer's and Parkinson's. It aims to identify genetic factors influencing prion replication and neurotoxicity, potentially leading to new diagnostics and treatments for these diseas…
Transmissible spongiform encephalopathies (TSE) are caused by the ordered aggregation of PrPC into prions consisting of PrPSc.
Similar pathogenetic principles operate in Alzheimer’s and Parkin-son’s disease, and a growing list of further diseases whose prevalence is steadily rising.
Familial TSE are invariably associated with PrPC mutations, and the dearth of genetic modifiers has hampered our understanding of prion diseases.
Therefore, the first objective of my proposal utilizes a cell-based hi…
UNIVERSITAT ZURICH
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