CORDIS Project
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This project focuses on understanding how Polycomb group proteins regulate gene expression in mammals, particularly in the context of stem cells and cancer. It aims to elucidate the mechanisms behind these proteins' targeting to specific genomic locations.
In mammals Polycomb group (PcG) repressors play a central role in maintaining cell type specific gene expression patterns in stem cells and through differentiation and development.
Accordingly, deficiencies in the Polycomb system are important in disease, notably in several types of cancer.
Although it is established that the effector function of PcG proteins is in large part attributable to intrinsic histone modification activities, the mechanisms that target PcG proteins to defined loci rema…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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