CORDIS Project
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This project investigates the mechanism of action of primases, enzymes essential for DNA replication. Using advanced spectroscopy techniques, it aims to provide insights into the dynamics of primer synthesis, which could inform cancer treatment strategies.
The replication of DNA and therefore of the genetic information is realized at the molecular level in three steps: helicases open the DNA, primases initiate the replication and polymerases use this primer to duplicate the DNA strand.
The precise mechanism of action of primases has up to now remain quite elusive and thus a better understanding of how primase works would be of great interest to fully understand the process of DNA replication.
Primases are classed into two groups, bacterial and ar…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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