CORDIS Project
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This project investigates the endocytic trafficking in polarized liver cells, focusing on how cargo is transported to distinct membranes. It aims to develop a mathematical model to predict endosomal behavior and understand signaling mechanisms in hepatocytes.
Hepatocytes as polarized cells consist of two distinct membranes, the apical (towards the bile) and the basolateral (towards the blood and each other).
Discrete endosomal networks and machineries are responsible for their proper maintenance and function.
Therefore, internalized cargo is delivered specifically via different populations of endosomes to the apical and basolateral membranes ensuring their specificity in trafficking and signaling.
Isolated mouse hepatocytes maintain polarity and in v…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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