CORDIS Project
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This project focuses on the genetic and epigenetic factors influencing the effectiveness and toxicity of the cancer drug 5-Fluorouracil. It aims to identify genetic variations that affect patient responses and develop a genetic testing tool to personalize cancer treatment.
5-Fluorouracil (5-FU) has been one of the most commonly used drugs in the treatment of various types of cancer (in particular, colorectal and breast) for the past fifty years. 5-FU is a drug for which genetic and epigenetic variation in the drug-metabolizing enzyme (dihydropyrimidine dehydrogenase [DPD]) and the drug target enzyme (thymidyalate synthase [TS]) can influence both toxicity and response to treatment.
Through a comprehensive investigation and screening of various genetic (SNPs, delet…
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