CORDIS Project
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This project aims to identify the signaling mechanisms involved in the formation of presynaptic terminals in neurons. It focuses on the role of local protein synthesis in neurodevelopment, particularly in the context of synapse assembly.
The objective of the proposed research is to identify the signaling mechanisms that lead to presynaptogenesis, the mechanism by which a functional presynaptic terminal is formed.
Postsynaptic mechanisms such as LTF (long-term facilitation) in invertebrate neurons, and LTP (long-term potentiation) and LTD (long-term depression) in mammalian neurons have been well characterized and shown to be dependent on local mRNA translation.
However, presynaptic protein synthesis has not been object of intens…
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