CORDIS Project
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This project investigates the mechanisms behind neonatal seizures caused by birth asphyxia. It focuses on the role of arginine vasopressin in triggering seizures and aims to uncover ionic regulation in the immature brain to improve treatment strategies.
A transient period of asphyxia in the newborn is an obligatory part of normal parturition. A more prolonged disturbance in cerebral blood supply is a major cause of neonatal seizures.
Current therapies of birth asphyxia seizures are ineffective and the underlying mechanisms are unknown.Our recent landmark work on a rat model of birth asphyxia showed that asphyxia is followed by brain alkalosis, which triggers seizures.
The brain-confined alkalosis is generated by activation of Na/H exchange in t…
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