CORDIS Project
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This project aims to improve organ transplantation outcomes by protecting grafted cells from T-cell mediated rejection. By leveraging insights from bacterial infections, the goal is to reduce reliance on immunosuppressive drugs, enhancing the quality of life for transplant recipients.
The success of organ transplantation depends on the lifelong use of immunosuppressive drugs to prevent rejection of the donor cells by the recipients immune system.
These immunosuppressive drugs have several limitations, most notably major side effects, namely opportunistic infections and cancers.
We have recently shown that the bacterial pathogen Listeria monocytogenes (Lm) induces the resistance of infected cells to T-cell mediated killing.
This project aims to protect grafted cells from T cel…
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