CORDIS Project
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This project investigates how drug-resistant mutations in HIV-1 develop in response to antiretroviral treatments. By applying molecular evolution and computational techniques, it aims to predict potential resistance variants, enhancing therapy selection for patients and providing insights into pathogen evolution.
Drug resistant mutations can appear when the selective pressure given by a pharmacological treatment causes the evolution ofpathogen proteins towards variants that become unaffected by the drug.
Currently, to select therapies against pathogens, genotypicresistance analyses and tables of resistance mutations are employed to decide the best treatment for the patients.
However, thesescreenings ignore evolutionary changes that can appear as pathogens adapt, potentially leading to drug resistance.
To…
UNIVERSIDAD DE VIGO
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