CORDIS Project
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This project investigates the role of Polycomb Group proteins in regulating gene expression and chromatin structure, particularly in the context of cancer. It aims to understand how these proteins contribute to cell identity and tumor progression, focusing on prostate cancer.
A key to development is the maintenance of various cell identities.
Despite identical genome sequence, in a defined organism, cells from different origins will have distinct pattern of gene expression.
The chromatin structure plays a pivotal role in the regulation of gene expression and contributes to this so-called ""epigenetic information"".
Different parameters defined the chromatin structure among which DNA methylation, histone variant incorporation and histone post-translational modificatio…
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