CORDIS Project
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The project investigates the role of T helper cell subsets in immune responses and disease. By analyzing T cell behavior in response to various stimuli, it aims to enhance understanding of immunity, tolerance, and autoimmunity, with potential implications for vaccine and therapy development.
The overall goal of this project is to test, in the human system, several hypotheses related to the role of T helper (Th) subsets in immunity and immunopathology.
Using an experimental approach that takes advantage of high throughput culture methods and combines the ex vivo analysis of memory T cells with the in vitro priming of naïve T cells, we will dissect the Th cell response to pathogens, allergens, and self-antigens, in terms of antigen-specificity, tissue tropism, and cytokine production.…
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