CORDIS Project
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This project focuses on developing Proteolysis Targeting Chimeras (PROTACs) that can selectively degrade difficult-to-target proteins. By designing innovative linkers that enhance the stability and formation of the ternary complex, the project aims to improve the efficiency of PROTACs in therapeutic applications.
Proteolysis Targeting Chimeras (PROTACs), small molecules capable of inducing degradation of a target protein, represent a novel strategy to design advanced chemical probes and therapeutic agents with the potential to target so far “undruggable” proteins. PROTACs are heterobifunctional molecules consisting of binding ligands to an E3 ubiquitin ligase and a protein of interest, covalently connected by a linker.
Formation of a ternary complex of target protein, PROTAC and E3 ligase allows ubiquiti…
UNIVERSITY OF DUNDEE
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