CORDIS Project
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This project focuses on developing precise cell replacement therapies for Parkinson's disease by generating specific types of neurons from human pluripotent stem cells. It aims to identify the factors that control neuron development to improve treatment efficacy.
Parkinson’s disease (PD) is a progressive incurable neurodegenerative disorder characterized by the loss of substantia nigra neurons (A9/SNs), a subset of midbrain dopaminergic neurons (mDAs) that are required for functional re-innervation of the striatum.
Current treatments for PD are symptomatic and do not prevent disease progression.
Proof-of-concept clinical studies using human fetal midbrain tissue for transplantation have shown that replacement of mDAs can change the course of PD.
Human pl…
KAROLINSKA INSTITUTET
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