CORDIS Project
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This project investigates meiotic recombination in sexually reproducing organisms, focusing on the role of the DNA-binding protein PRDM9. It aims to map the genome-wide distribution of PRDM9 and identify additional factors influencing recombination events.
Meiotic recombination is an essential process for sexually reproducing organisms.
The appropriate genomic distribution of recombination events is necessary for the accurate transmission of genetic information from one generation to the next.
Extensive research has demonstrated that a major determinant of recombination sites in mice and humans is the DNA-binding protein PRDM9.
An intriguing feature of PRDM9 is the exceptionally rapid evolution of its DNA-binding domain, which causes enormous vari…
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