CORDIS Project
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This project aims to discover and optimize small molecules that disrupt the protein-protein interactions between the oncogene MDM2 and the tumor suppressor p53, as well as MDM4. By combining computer simulations with biophysical experiments, it seeks to develop effective cancer therapies and establish design principles…
Many biological processes are orchestrated by complex networks of protein-protein interactions and several diseases can be linked to deregulations of these convoluted networks.
In spite of their central importance in diseases, very few existing drugs act by disrupting abnormal protein-protein interactions.
The discovery of small molecule able to disrupt critical protein-protein interactions has long been considered a very difficult task.
Yet, recent successes suggest that this endeavor is feasib…
THE UNIVERSITY OF EDINBURGH
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