CORDIS Project
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This project focuses on intrinsically disordered proteins and their role in drug discovery. It aims to stabilize protein-protein interactions using small molecular glues to develop new therapies for neurodegenerative diseases.
Intrinsically Disordered Proteins (IDPs) represent one of drug discovery’s major challenges.
Due to their high degree of conformational freedom, IDPs have no defined pockets for binding small molecules.
Molecular glues that can strengthen protein-protein interactions (PPIs) are a revolutionary technology for drug discovery.
The hub protein 14-3-3 regulates many IDPs via phosphorylation-dependent PPIs.
Stabilization of 14-3-3 PPIs with small molecular glues provides a unique entry point to render…
TECHNISCHE UNIVERSITEIT EINDHOVEN
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