CORDIS Project
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The project aims to synthesize Madagamine alkaloids through a novel chemical pathway involving organocatalysis. It focuses on efficiently constructing the complex molecular structure of these compounds, which are known for their biological activity, using selective and scalable methods.
The projet concerns the development of a powerful first total synthesis of the Madagamine alkaloids.
The route starts with an organocatalytic enantioselective and diastereoselective Michael addition of cyanoacetate pronucleophiles to a nitrocyclohexene derivative, as a key step to the formation of the ABC core.
When the product of this reaction is subjected to a nitro-Mannich, Mannich reaction cascade this should allow us to construct the core of the madangamine alkaloids rapidly, selectively an…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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