CORDIS Project
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This project explores the role of the gut microbiome in enhancing the effectiveness of chimeric antigen receptor T cell therapy for treating resistant B cell cancers and myeloma. It aims to identify how microbiome configurations influence treatment responses and to develop strategies to improve patient outcomes through…
T cell therapy with chimeric antigen receptor (CAR)-T cells is a curative-intent, transformative treatment aimed to boost antitumor abilities of host T cells against refractory/relapsed B cell malignancies and, recently, against refractory/relapsed myeloma.
Major challenges of current CAR-T cell immunotherapies are the loss of long-term efficacy, the occurrence of toxicities including infections, and a lack of personalized patient strategies including biomarkers for response prediction and inter…
EBERHARD KARLS UNIVERSITAET TUEBINGEN
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