CORDIS Project
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This project aims to investigate endometrial dysfunction in women with Polycystic Ovary Syndrome (PCOS) at a single-cell level throughout the menstrual cycle. By analyzing human endometrial biopsies and developing patient-derived cell models, it seeks to identify potential targets for drug development to improve diagno…
Polycystic ovary syndrome (PCOS) affects 11-13% of reproductive-age women and is one of the leading causes of anovulatory infertility.
Women with PCOS have elevated androgen levels, polycystic ovarian morphology, and ovarian dysfunction.
The PCOS endometrium is exposed to constant estrogen, which leads to progesterone resistance and impaired decidualization.
As a result, PCOS women are twice as likely to have a non-receptive endometrium.
This hinders embryo implantation and increases the risk of…
KAROLINSKA INSTITUTET
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