CORDIS Project
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This project investigates how T helper cells influence B cell behavior in germinal centers by examining gene expression and protein stability. Using advanced imaging techniques, it aims to clarify the mechanisms that regulate antibody production and B cell fate, with potential applications in vaccine development and au…
Enduring protection from pathogens and robust responses to vaccination depend on the generation of high-affinity antibodies through the germinal center (GC) reaction.
In GCs, T helper cells promote the extensive proliferation of high-affinity B cell clones and their differentiation into plasma cells through cellular interactions that modulate gene expression.
Here, we aim to unravel multiple post-gene expression mechanisms, including mRNA and protein stability regulation, that jointly control t…
WEIZMANN INSTITUTE OF SCIENCE
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