CORDIS Project
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This project investigates how variations in one-dimensional DNA sequences influence the three-dimensional structure of genomes, impacting gene expression and phenotypes. Using a controlled chicken cohort, it aims to create a catalog of DNA variants that shape 3D genome architecture, potentially advancing understanding…
The linear one-dimensional (1D) DNA fiber inside each Eukaryotic cell nucleus folds into a precise three-dimensional (3D) structure, whose structural preservation is vital for correct cell homeostasis and gene-regulatory mechanisms.
Previous studies showed that if 3D structure is altered, aberrant phenotypes and diseases can arise.
However, little is known on how 1D variation can affect 3D genome variation.
Although recently developed technologies allow researchers to generate data to characteri…
KOBENHAVNS UNIVERSITET
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