CORDIS Project
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This project investigates the genetic and epigenetic factors affecting oocyte competence in women with polycystic ovarian syndrome. It aims to develop improved in vitro maturation techniques to enhance fertility outcomes for affected patients.
Polycystic ovarian syndrome (PCOS) is the leading endocrine and metabolic disorder in women, with a prevalence of 5-20%.
It is characterized by hyperandrogenism, ovulatory dysfunction, polycystic ovarian morphology and infertility.
Epigenetic factors have garnered attention in the pathogenesis of PCOS since changes in DNA methylation and gene expression have been reported in various tissues.
Whether these alterations are also found in PCOS oocytes remains unknown.
Cumulus cells (CCs) are special…
VRIJE UNIVERSITEIT BRUSSEL
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