CORDIS Project
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This research focuses on creating a new polymer-drug conjugate for targeted delivery of anti-cancer drugs. By developing a thermo-responsive and pH-sensitive gel, the project aims to improve the precision and efficiency of drug release directly at tumor sites, minimizing exposure to healthy tissues.
The aim of this research program is to achieve secure delivery, targeted release and high loading of anti-cancer drugs conjugated with polymers utilizing the following two components.
First, the proposed plan involves developing a new polymer-drug conjugate composed of poly(N-(2-hydroxypropyl) methacrylamide) (PHPMA) and anti-cancer drugs containing no amine groups in their chemical structures including docetaxel (DTX). PHPMA is widely conjugated with drugs, and DTX has been reported as an effic…
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