CORDIS Project
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This project investigates long non-coding RNA (lncRNA) to understand their transcription mechanisms and potential functions. It aims to identify which lncRNA are likely functional by studying their promoters, terminators, and transcription termination processes.
.Mammalian transcriptome analysis reveals that while most of the genome is transcribed, only a minority fraction produces protein coding, messenger RNA or functional, structural RNA.
Instead a substantial fraction is transcribed, often tissue specifically, into long non coding (lnc)RNA of mostly unknown function.
Many lncRNA are rapidly degraded and may reflect promiscuous, non-functional transcription.
However some lncRNA have important cellular functions. I reason that defining promoters and…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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