CORDIS Project
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This project investigates the process of adding poly-adenine tails to mRNA during transcription. It aims to understand the structural mechanisms behind this essential step in RNA processing, which is crucial for proper gene expression and related diseases.
RNAs transcribed by RNA polymerase II (Pol II) undergo numerous modifications before becoming export competent mature mRNA.
One key step is the addition of the poly-adenine (poly-A) tail, which involves cleavage of the pre-mRNA from the growing RNA chain and the subsequent polyadenylation by poly-A polymerase.
This cascade of events is known collectively as 3’-end processing and is one of the least understood steps of mRNA biogenesis.
Pol II plays a vital role in recruiting and assembling the 3’…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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