CORDIS Project
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This project investigates the role of poised enhancers in gene expression during embryonic stem cell differentiation. By examining the unique features of these regulatory elements, the research aims to uncover mechanisms that ensure precise gene activation in neural development.
The mechanisms that, despite the noisy and stochastic nature of transcription, enable the specific, precise and robust deployment of developmental gene expression programs are poorly understood.
We previously identified Poised Enhancers (PEs) as a conserved set of cis-regulatory elements essential for the induction of major anterior neural genes upon ESC differentiation.
Importantly, before becoming active in anterior neural progenitors, PEs are already bookmarked in embryonic stem cells (ESC) w…
UNIVERSIDAD DE CANTABRIA
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