CORDIS Project
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This project investigates the role of phenotypic variation in bacterial populations, particularly Streptococcus pneumoniae, and its impact on infection outcomes and antibiotic resistance. By utilizing advanced imaging and genetic engineering techniques, the project aims to uncover the mechanisms behind this variability…
Within clonal bacterial populations not all cells exhibit the same phenotype, even though they grow in the same environment.
The molecular sources contributing to phenotypic variation are diverse and can originate from noise in gene expression to heterogeneity in growth rates or cell cycle state.
Phenotypic variation helps pathogenic bacteria to elude the host immune response or resist antibiotic pressure.
Vice versa, there is cell-to-cell variability in the host’s response towards pathogens tha…
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