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The project 'PMLingAML' investigates the role of Pml nuclear bodies in acute promyelocytic leukemia and other acute myeloid leukemia subsets. By utilizing a novel mouse model and advanced imaging techniques, the project aims to uncover mechanisms that could enhance treatment strategies for leukemia patients.
Understanding the initiation and development of acute myeloid leukemia (AML) represents an important challenge which may lead to the identification of new therapeutic strategies.
Acute promyelocytic leukemia (APL) was formerly the most lethal subset of AML; however, today the vast majority of APL patients can be cured by combination therapy.
Therefore, fully understanding the mechanisms underlying successful treatment, by analysing the biology of APL pathogenesis will assuredly improve the manag…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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