CORDIS Project
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The PLEIOTROPY project investigates how single genes influence multiple traits in rodents, particularly focusing on molar development. By studying genetic variations and their compensatory effects, the project aims to understand the evolutionary dynamics of pleiotropy.
Pleiotropy is the phenomenon of one gene affecting several phenotypic traits, such as different organs.
Mutations advantageous in one organ often have antagonistic effects in others.
Recent theoretical and empirical data suggest adaptation proceeds with such pleiotropic mutations if they are compensated during development. I think that pleiotropy may promote the fast divergence of developmental gene expression and cis-regulatory regions while selecting for such compensations.To test this, my lab…
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