CORDIS Project
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The PLEIADES project investigates how bacterial defense systems influence the evolution of plasmids, which are genetic elements that can carry antimicrobial resistance genes. By developing computational models, the project aims to understand the relationship between plasmid diversity and bacterial defense mechanisms, u…
Plasmids are self-copying genetic elements that can move between bacterial species.
They frequently carry antimicrobial resistance (AMR) genes, making understanding the factors that affect their spread through bacterial communities an urgent challenge.
Exploiting bacteria’s natural defence systems to block plasmid spread is an exciting possibility.
Recent years have seen a huge increase in the known number of ‘anti-phage’ systems that stop bacterial viruses (phage) from gaining a foothold in the…
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