CORDIS Project
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This project aims to uncover new therapeutic targets for calcific aortic valve disease by investigating the role of platelets in disease progression. It utilizes advanced proteomics and 3D bioprinted models to explore sex-specific mechanisms of the disease.
Calcific aortic valve disease (CAVD) is an increasing global health burden.
Once symptomatic and untreated, CAVD confers a 2-year mortality rate of ~50%.
Crucially, costly and highly specialised valve replacement surgery remains the only treatment.
Additionally, while male and female patients present with calcific or fibrotic tissue degeneration, respectively, experimental studies mostly use male models.
The rising disease burden, lack of understanding of differential pathophysiological mechanis…
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
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United States, Boston
Type: Research institute
Activity type: Research Organisations
SME: No
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