CORDIS Project
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This project investigates the unique properties of human naïve pluripotent cells, particularly their ability to form extraembryonic tissues, challenging traditional views on cell lineage. By studying various species, the project aims to uncover the evolutionary basis of pluripotency and develop advanced stem cell lines…
A few days after fertilisation mammalian embryos form a blastocyst comprised of three tissues; trophoblast and hypoblast are the forebears of extraembryonic structures, while naive epiblast cell are the pluripotent source of the embryo proper.
Classical mouse embryological studies indicate that lineage potencies are determined concomitant with segregation of the three founder tissues.
Textbook definitions of pluripotency thus exclude extraembryonic potential.
Consistent with this paradigm, mouse…
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