CORDIS Project
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This project investigates a novel gene silencing mechanism in the malaria parasite Plasmodium falciparum, focusing on the role of an exoribonuclease in regulating gene expression related to severe malaria. Using advanced genome editing techniques, it aims to uncover the molecular processes involved in this regulation.
Background:
The human protozoan malaria parasite P. falciparum causes approximately 200 million infections and 0.7 million deaths (mainly children) per year.
In the well-studied asexual blood stages, cyclic monocistronic gene activation occurs at the transcriptional level; however, relatively few transcription factors have been identified, thus other types of regulatory processes that contribute to this coordinated gene expression are believed to exist.
Through the study of molecular process of…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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