CORDIS Project
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This project investigates the axon initial segment of neurons, focusing on how its plasticity affects neuronal excitability and network stability. By utilizing advanced imaging and genome editing techniques, it aims to understand the molecular mechanisms behind this adaptability and its implications for diseases like A…
Neurons have the remarkable ability to continuously integrate and propagate information while maintaining their activity state within physiological range.
The axon initial segment (AIS) is the keystone of neuronal excitability and pivotal for the maintenance of network homeostasis.
The molecular organization of the AIS dictates the generation of action potentials, and thereby shapes the principal output of neurons.
Although the AIS has long been considered as a static and passive structure, rece…
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