CORDIS Project
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This project investigates how small RNAs in mosquitoes protect against viral infections, focusing on the role of PIWI-interacting RNAs in the germline. It aims to develop tools for gene inactivation to enhance our understanding of virus-host interactions and to create strategies for mosquito-borne disease control.
Background:
The mosquito Aedes aegypti transmits viruses with pandemic potential but is also host to a large repertoire of mosquito-specific viruses and endogenous retroviruses.
These viruses may invade the ovaries and eventually the oocyte to be transmitted from mother to offspring and to expand in the population.
This transmission route exposes them to the specific host defense mechanisms of the ovary, which they must overcome to ensure onward transmission.
This intriguing virus–host conflict…
STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
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