CORDIS Project
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This project investigates the role of small RNAs, specifically piwi-interacting RNAs, in silencing transposons to maintain genome stability in mammals. By utilizing biochemistry, genetics, and bioinformatics, it aims to identify new components involved in piRNA biogenesis and function, enhancing our understanding of ge…
Transposons are parasitic DNA elements that when activated can insert into new genomic locations, leading to genomeinstability.
Animal germlines express a special class of small RNAs called piwi-interacting RNAs (piRNAs) which areimplicated in transposon silencing.
In mammals, they are believed to promote DNA methylation of transposon-rich genomicregions.
Mechanisms of piRNA biogenesis and function are only beginning to be understood.
Sequence analysis of piRNAsfrom a variety of organisms has gi…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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