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The PiloSyn project aims to identify the biosynthesis pathway of pilocarpine, a compound used in treating glaucoma and dry mouth, using synthetic biology. By elucidating this pathway in yeast, the project seeks to create a sustainable production method, reducing reliance on wild Pilocarpus plants and protecting their n…
Pilocarpine is a plant-derived alkaloid used to treat primary angle closure glaucoma and dry mouth.
To meet the commercial demand for pilocarpine, the alkaloid is extracted from wild Pilocarpus plants in the Amazon rainforest.
Excessive harvesting of wild populations has led to the official listing of several Pilocarpus species as threatened.
Synthetic biology offers a sustainable approach for pilocarpine production.
However, to produce the compound in heterologous hosts such as yeast, the biosy…
KOBENHAVNS UNIVERSITET
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