CORDIS Project
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This project focuses on developing a cost-effective method for screening functional proteins using microdroplets in microfluidic devices. By linking phenotypes to genotypes, it aims to enhance the directed evolution of enzymes and metagenomic screening for biocatalysis applications.
Directed evolution of functional proteins has arguably emerged as an approach to protein engineering that can complement or better design-led approaches to protein function.
However, as a random process, enormous numbers of variants have to be screened and selected to have a chance to identify successful catalysts.
This process is costly and cumbersome:
Industrial screening facilities require investment of tens to hundred millions of dollars.
My group has implemented key steps towards conducting…
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