CORDIS Project
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This project investigates the role of the p53 protein in maintaining the integrity of epithelial tissues and preventing invasive behavior in cells. By studying mouse models of inflammatory bowel diseases and intestinal cancer, the research aims to uncover mechanisms that could inform new cancer therapies and improve di…
Background:
Our recent studies implicate p53 in gut tissue homeostasis - suppressing epithelial invasion.
This function is tightly linked to suppression of a gene cluster (PSIS- p53-Suppressed Invasiveness Signature), which requires Wnt activation and other cues, yet is only expressed upon loss of p53.
The invasive signature explains a broad spectrum of the invasiveness property, from the loss of enterocyte polarity to matrix degradation, pointing to a concerted action.
We documented a tight ass…
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