CORDIS Project
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This project investigates the role of plasma membrane tension and specific lipids in the asymmetric division of the nematode Caenorhabditis elegans. By studying the interactions of proteins and lipids, it aims to uncover fundamental mechanisms that govern cell division and development.
The first embryonic division of Caenorhabditis elegans is a powerful system to dissect the mechanisms governing asymmetric division, which relies on PAR-proteins for cell polarity and on dynein-dependant forces for centrosome and spindle positioning.
In contrast to the extensive knowledge regarding proteins regulating asymmetric division, the contribution of plasma membrane tension, as well as of PIP2 and its modulators PPK-1 and CSNK-1 is poorly understood. I propose to decipher these questions…
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
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